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Transgender and gender-diverse people have been documented globally for millennia, from the of South Asia and Two-Spirit individuals in Indigenous North American cultures to the Koekchuch of Siberia.

The modern medical story began in early 20th-century Germany. In 1919, founded the Institut für Sexualwissenschaft (Institute for Sexual Science) in Berlin, which pioneered gender-affirming healthcare and provided the first formal studies on gender dysphoria. In 1931, Dora Richter became the first known transgender woman to undergo a full vaginoplasty at the institute. The Mid-Century Spark Christine Jorgensen young tyny shemales

The story of the transgender community and its intersection with broader LGBTQ culture is one of ancient existence, early 20th-century scientific pioneering, and mid-century uprisings that birthed the modern movement. Ancient & Early Foundations early 20th-century scientific pioneering