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In patients with idiopathic pulmonary arterial hypertension, a higher plasma MMP2/TIMP4 ratio is used as a predictor of disease severity and worsened survival. 3. Role in Pregnancy and Tissue Remodeling

The decrease in TIMP4 serves as a strong indicator of a poor prognosis, positioning it as a novel potential biomarker for tracking tumor progression. 2. Cardiovascular and Inflammation Protection Titlimp4

Tissue inhibitor of metalloproteinases 4 (TIMP4) belongs to a crucial family of proteins designed to keep the body’s extracellular matrix (ECM) in balance. It acts as an inhibitor of matrix metalloproteinases (MMPs), which are enzymes that break down connective tissue. Lower levels of TIMP4 are directly correlated with

Lower levels of TIMP4 are directly correlated with metastasis and higher clinical staging. particularly within adipose tissue.

Specific genetic variations (C>T polymorphism) in the TIMP4 gene have been associated with a protective effect against preeclampsia in pregnant women. TIMP4 vs. Other TIMPs

Recent studies in 2025 demonstrate that .

TIMP4 is highly expressed in human cardiovascular tissue, particularly within adipose tissue.