Senescence 〈Pro – Review〉

: The overall decline in an individual's health, leading to increased death rates and decreased fertility.

Senescence is the biological process of , characterized by a gradual decline in the functional capabilities of cells and whole organisms. It acts as a double-edged sword: while it prevents the growth of damaged or cancerous cells, the long-term accumulation of these "zombie cells" drives chronic inflammation and age-related diseases. The Two Levels of Senescence Senescence

Senescent cells are identified by specific physical and chemical changes: : The overall decline in an individual's health,

: A state where cells permanently stop dividing but do not die, triggered by stressors like DNA damage or telomere shortening. Key Hallmarks of Senescent Cells Senescence

Uncovering the Signatures of Cellular Senescence ... - bioRxiv