Use the L1 (or equivalent) button to switch between two weapon loadouts instantly. A popular strategy is to have a heavy melee set for close combat and a wand or bow for ranged safety.
If you are playing on PC, check out the official Salt and Sanctuary Enhanced update which rebalanced math, stats, and fixed long-standing glitches.
Don't sell boss drops like ears or eyes. These are used at an Alchemist to transmute standard weapons into powerful boss-themed gear.
Avoid leveling stats like Strength or Dexterity past 50 , as you will see significantly diminishing returns beyond this point. Key Community Resources
A standard focused run takes about 16.5 hours , while a 100% completionist run typically lasts around 32 hours .