[s5e22] What A Difference A Day Makes -

: Despite the shift in plans, the wedding remains a fan favorite, featuring the original "MAGIC" interns (Meredith, Alex, George, Izzie, and Cristina) as the wedding party.

: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately. [S5E22] What a Difference a Day Makes

: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances. : Despite the shift in plans, the wedding

While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation. While the wedding takes center stage, the hospital

: Rhimes described the episode as the moment Meredith evolved from a "dark and twisty" girl into an "extraordinary" woman capable of choosing happiness.

The episode's central plot twist occurs when Meredith and Derek decide to give their meticulously planned wedding to Izzie and Alex.

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts