: Savannah insists on the surgery due to her family history and the BRCA gene, eventually gaining Weiss's reluctant support after a discussion with Derek.
The primary conflict revolves around Savannah and Weiss, a married couple from New York. Savannah, having lost several female relatives to cancer, seeks a preemptive double mastectomy and hysterectomy despite not currently having the disease. This request causes significant discord, as Weiss struggles to support the decision, while Addison and Derek find their own strained marriage further tested by the case. Key Medical Cases & Subplots [S2E8] Let It Be
Directed by and written by Mimi Schmir , the episode features the series' core ensemble alongside notable guest stars. Ellen Pompeo as Meredith Grey Patrick Dempsey as Derek Shepherd Sandra Oh as Cristina Yang Katherine Heigl as Izzie Stevens Chandra Wilson as Miranda Bailey Guest Stars Arija Bareikis as Savannah Joseph Lyle Taylor as Weiss Shelley Berman as Jed Sorento Production Details Original Air Date : November 13, 2005 Network : ABC : Savannah insists on the surgery due to
: Primarily at the Veterans Hospital in North Hills, CA, which doubles for Seattle Grace. This request causes significant discord, as Weiss struggles
: Cristina Yang and Preston Burke attempt their first "normal" date outside the hospital. The evening is saved from total awkwardness only when they must work together to save a man having a heart attack in the restaurant. Cast & Crew