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: High-dose estrogen regimens used in earlier decades were linked to an increased risk of cardiovascular death , though modern, lower-dose regimens aim to mitigate these risks.

Research into long-term health for MtF individuals highlights both the benefits of gender-affirming care and unique risks: rate shemales

Studies have examined how MtF individuals are perceived and how they navigate social binaries: : High-dose estrogen regimens used in earlier decades

Surgical interventions, such as vaginoplasty, are generally associated with high levels of satisfaction: such as vaginoplasty