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premiered on March 27, 2005, and has since become the longest-running primetime medical drama in TV history. Created by Shonda Rhimes , the series initially centered on Meredith Grey (portrayed by Ellen Pompeo ) and her fellow interns—Cristina, Izzie, George, and Alex—at Seattle Grace Hospital. Series Overview

: As of 2026, Ellen Pompeo , Chandra Wilson (Miranda Bailey), and James Pickens Jr. (Richard Webber) are the only original cast members still appearing on the show. premiered on March 27, 2005, and has since

: Over 20+ seasons, the hospital has been renamed several times, eventually becoming Grey Sloan Memorial Hospital . (Richard Webber) are the only original cast members

: The series remains a massive cultural staple and was recently renewed for a 23rd season . Iconic Quotes Iconic Quotes : The show masterfully blends intense

: The show masterfully blends intense medical cases with complex relationships and emotional personal growth .