: Observations of "leader cells" responding to GLI2 inhibition.
: Injured epithelial cells release Sonic Hedgehog (SHH) ligands. g9048.mp4
: The resulting stiffened tissue triggers non-canonical activation of the transcription factor GLI2 in epithelial cells. : Observations of "leader cells" responding to GLI2
: Time-lapse footage of cancer cells moving across substrates of varying stiffness. g9048.mp4
: This signaling activates fibroblasts, which increase tissue stiffness by producing collagen.
: This "chemo-mechanical" loop promotes cell proliferation, migration, and the transition of normal cells into invasive cancer cells. Potential Video Content
: Visual evidence of cell mobility and invasiveness.