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Unlike strict alternate picking (Down-Up-Down-Up), Gambale’s method uses a whenever moving to an adjacent string:
Gambale designed his system around specific scale fingerings. Playing three notes on one string (Down-Up-Down) sets your pick up perfectly to "sweep" into the next string with another Downstroke.
High speed requires "gracing" the strings rather than digging in. The pick should feel like a machine part where the strings are just "in the way".
If you finish a phrase on a downstroke and the next note is on a higher string, you continue with a Downstroke .
Consistent patterns—like playing four notes on one string to reverse direction—help automate the technique so you don't have to think about every stroke. Essential Training Resources