The condition stems from a in the GNAS gene . This mutation is not inherited from parents but occurs spontaneously during early embryonic development.
Affects multiple bones. This form typically presents earlier in childhood and is more severe.
Affects a single bone. It accounts for about 70-80% of cases and is often asymptomatic until discovered incidentally on an X-ray. fibrous dysplasia of bone
A triad of polyostotic FD, café-au-lait skin spots (often with jagged "Coast of Maine" borders), and hyperfunctioning endocrine issues like precocious puberty. Symptoms and Complications
Because the mutation happens after fertilization, only some cells carry it. This results in a patchy, variable distribution of the disease across the body. Clinical Classification The condition stems from a in the GNAS gene
The mutation leads to continuous activation of the Gsα protein, increasing cAMP levels.
Osteoblasts (bone-forming cells) fail to mature, producing disorganized "woven bone" instead of strong "lamellar bone". This form typically presents earlier in childhood and
Symptoms vary widely based on the location and extent of the lesions: Fibrous Dysplasia - StatPearls - NCBI Bookshelf