Law — Distribution

The two solvents must not dissolve in one another.

If the distribution coefficient and the solubility of a solute in one solvent are known, its solubility in the second solvent can be calculated. distribution law

are the equilibrium concentrations of the solute in Solvent 1 and Solvent 2. KDcap K sub cap D is the Distribution Coefficient (or Partition Coefficient). Necessary Conditions and Limitations The two solvents must not dissolve in one another

The law states that at a constant temperature, a solute will distribute itself between two immiscible liquids in such a way that the ratio of its concentrations in the two layers is constant, provided the solute exists in the same molecular state in both solvents. Mathematically, this is expressed as: KDcap K sub cap D is the Distribution

The law is most accurate at low concentrations, where the solute behaves ideally.

The principle of a solute partitioning itself between a mobile phase and a stationary phase is the fundamental mechanism behind various chromatographic separation techniques. Conclusion