Some anime utilize more stylized or fantasy elements to explore gender: The Trans One Piece Episode
These series are widely recognized for including canonically transgender characters or core narratives centered on gender transition: big tranny anime
If you're looking for anime featuring transgender characters or exploring themes of gender identity, several series stand out for their portrayals. Some shows offer thoughtful narratives on the trans experience, while others—like the long-running One Piece —feature a wide range of gender-nonconforming and trans characters. Some anime utilize more stylized or fantasy elements