In the field of neurology, Akari Yamazaki is a prominent research researcher at the Mayo Clinic Department of Neuroscience. Her work primarily revolves around understanding how the brain's complex vascular systems intersect with neurodegenerative diseases like Alzheimer's disease (AD). Pioneering Brain Vascular Profiling
This technique was detailed in the established protocol paper featured in STAR Protocols , which allows researchers to execute high sequencing depth of mouse brain vascular cells to study brain diseases. The Role of ApoE4 and Cerebrovascular Function akari yamazaki
One of Yamazaki’s most notable technical contributions to the scientific community is her work on profiling the transcriptomics of the blood-brain barrier. In the field of neurology, Akari Yamazaki is
: Her research published in journals like Arteriosclerosis, Thrombosis, and Vascular Biology has demonstrated that ApoE in Brain Pericytes regulates endothelial cell phenotype. This showed that ApoE4 impairs the basement membrane formation of capillaries, contributing to cognitive decline. The Role of ApoE4 and Cerebrovascular Function One
She established highly specialized cell isolation procedures to secure glio-vascular cell-enriched single-cell suspensions.