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Found to be upregulated in the HCC microenvironment, agrin promotes cancer cell proliferation and "stiffness" of the tumor tissue, which helps the cancer spread.

Recent trials use engineered T cells to target GPC3 , effectively seeking out and destroying only the cancer cells expressing this protein. 27879.rar

Proteoglycans (PGs) are heavily glycosylated proteins found in the extracellular matrix (ECM). In the context of liver cancer, they act as a "double-edged sword," either promoting or inhibiting tumor progression depending on their specific type and the stage of the disease. Key Proteoglycans and Their Roles Found to be upregulated in the HCC microenvironment,

The "solid" clinical takeaway is that these molecules are becoming primary targets for precision medicine: they act as a "double-edged sword