1. Pilling Them Softly Online

Critics and fans often cite the episode for its sharp commentary on over-medication and its use of the 250th milestone to blend classic character rivalries with timely pop culture parodies.

: In his cooking segment, Peter attempts the "cinnamon challenge," which involves trying to eat a spoonful of ground cinnamon without water. 1. Pilling Them Softly

" Pilling Them Softly " is the first episode of the 14th season of and its 250th episode overall, airing originally on September 27, 2015. The episode features two main plotlines: Critics and fans often cite the episode for

: After Stewie is diagnosed with ADD, he is prescribed Adderall. Brian, ever the struggling writer, decides to take the pills himself to fuel a massive 2,000-page book proposal for author George R.R. Martin. Peter attempts the "cinnamon challenge